Kostas Vekrellis on In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice.
COMMENT This is an elegant study by the Holtzman group which clearly shows that yet another neurodegenerative disease-associated protein, thought to be cytosolic, is found extracellularly in the brain parenchyma. Using an optimized in-vivo microdialysis approach